Research
Micronutrients & recovery
Orlistat reduces the absorption of fat-soluble vitamins (specifically D and E) and beta-carotene, necessitating daily multivitamin supplementation taken 2 hours before or after the drug.
Take a standard multivitamin every day while on Orlistat. Take it at least 2 hours before or 2 hours after your Orlistat dose to ensure your body can absorb the vitamins, as the drug blocks fat-soluble vitamin absorption.
StrongQualifiesVERY_HIGH confidence
Because orlistat may decrease the absorption of fat-soluble vitamins, a standard multiple-vitamin supplement is recommended daily during therapy to prevent abnormalities in vitamin serum concentrations.
Why this rating
Consistently observed across multiple trials and explicitly stated as a recommendation.
Source
Orlistat, a New Lipase Inhibitor for the Management of Obesity
Amy Sheehan et al. · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · 2000
narrative_reviewCited 554×
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