Energy balance
Early menarche is associated with an increased risk of NAFLD in adulthood, primarily driven by excess adiposity rather than estrogen activation itself.
Women who start their periods early should be vigilant about weight management. Although early estrogen exposure is generally protective, it is often linked to higher body fat later in life, which cancels out that protection and increases the risk of fatty liver disease.
it has been suggested that early menarche may confer an increased risk of NAFLD in adulthood, excess adiposity being the primary culprit of this association.
Why this rating
The paper states 'it has been suggested', indicating this is a finding from specific studies rather than a universal consensus, and it is mediated by obesity.
Source
NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk
Stefano Ballestri et al. · Advances in Therapy · 2017
DOI 10.1007/s12325-017-0556-1
More from this paper
- Premenopausal women are protected from developing NAFLD due to estrogen-mediated partitioning of fatty acids toward ketone body production and sex-specific browning of white adipose tissue, whereas postmenopausal estrogen deficiency facilitates massive hepatic steatosis and fibrotic progression.Good
- Postmenopausal women have a higher prevalence of NAFLD than premenopausal women, and this risk is independently associated with menopause status even after adjusting for metabolic factors in some studies.Good
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →