Hormonal
Genetic manipulations that interfere with dietary restriction-mediated lifespan extension (DR-essential genes) identify key pathways where DR acts, and some genes act as genetic DR mimetics by extending lifespan even without DR.
Research into DR-essential genes and genetic mimetics (like the growth hormone receptor) offers potential targets for pharmacological interventions that mimic the benefits of caloric restriction without the need for severe dietary restriction. This suggests future drugs could target these pathways to extend healthspan.
A subset of these genes act as genetic DR mimetics, as their manipulation leads to an increased lifespan for ad libitum fed animals, which is not further extended by DR. One such example is the growth hormone receptor gene in mice (16), in fact the only mouse gene currently in GenDR.
Why this rating
Based on curated database entries of genetically modified model organisms, providing high-quality curated data.
Source
Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing
Robi Tăcutu et al. · Nucleic Acids Research · 2012
DOI 10.1093/nar/gks1155
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