Mixed
Dietary restriction (DR), particularly caloric restriction, is the most robust non-genetic intervention shown to extend lifespan across multiple species, from yeast to mammals.
While the paper does not provide a human protocol, it establishes that caloric restriction is the most robust non-genetic method for extending lifespan in biological models. For humans, this translates to exploring nutrient-dense, energy-restricted diets under medical supervision, with the goal of mimicking the genetic and metabolic benefits observed in model organisms, such as those identified in the GenDR database.
DR, of which caloric restriction is the most widely studied regimen, is the most robust non-genetic intervention shown to extend lifespan in a multitude of species, from yeast to mammals (12,14).
Why this rating
The claim is based on a consensus of findings across multiple model organisms (yeast, worms, flies, mice) cited in the database, though the paper itself is a database description rather than a primary experimental study.
Source
Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing
Robi Tăcutu et al. · Nucleic Acids Research · 2012
DOI 10.1093/nar/gks1155
Related findings · Mixed
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