Research
Hormonal
Rosiglitazone increases serum adiponectin concentrations and adipose tissue gene expression of PPAR-gamma, adiponectin, and lipoprotein lipase, whereas metformin does not.
Rosiglitazone significantly boosts adiponectin, a hormone that improves insulin sensitivity and reduces liver fat. Metformin does not have this effect on adiponectin levels.
GoodQualifiesHIGH confidence
Serum adiponectin concentrations increased by 123% with rosiglitazone but remained unchanged during metformin treatment... Rosiglitazone but not metformin significantly increased expression of peroxisome proliferator-activated receptor-gamma, adiponectin, and lipoprotein lipase in adipose tissue.
Why this rating
Measured using ELISA and RT-PCR, robust methods, but small sample size.
Source
Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes
Mirja Tiikkainen et al. · Diabetes · 2004
DOI 10.2337/diabetes.53.8.2169
rct · n=20Cited 525×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Rosiglitazone reduces liver fat content and increases insulin clearance in patients with type 2 diabetes, whereas metformin improves hepatic insulin sensitivity without altering liver fat.Good
- Rosiglitazone increases insulin clearance in patients with type 2 diabetes, which contributes to the decrease in fasting serum insulin concentrations.Good
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