Research
Hormonal
Strenuous or excessive exercise without proper training adaptation can be detrimental, leading to increased oxidative stress, hormonal imbalance, and immune suppression.
Avoid excessive exercise if you are untrained. Start with moderate activity and progress gradually to allow your body to adapt and detoxify ROS effectively, preventing negative hormonal and immune effects.
ModerateRefutesMEDIUM confidence
Therefore, excessive physical exercise is detrimental to untrained individuals, but progressive training allows the cells to more easily detoxify a larger amount of ROS. An excessive physical activity could be detrimental when it induces an altered hormonal activity, changes of the sleep-wake rhythm, of the appetite, alterations of the arterial pressure and of the heart rate.
Why this rating
Review paper summarizing known risks of overtraining.
Source
Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging
Carolina Simioni et al. · Oncotarget · 2018
DOI 10.18632/oncotarget.24729
narrative_reviewCited 511×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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