Research
Micronutrients & recovery
Supplementation with specific polyphenols (quercetin, resveratrol, curcumin) activates SIRT1, which modulates AMPK and mTOR pathways to support mitochondrial biogenesis and reduce oxidative stress.
If you are an endurance athlete, consider quercetin supplementation (1000mg/day) for 6 weeks to potentially reduce markers of oxidative stress (MDA). However, prioritize regular exercise as the primary driver of health.
ModerateSupportsMEDIUM confidence
Many studies in recent years have highlighted the correlation of SIRT1 activity with AMPK and mTOR pathway [114–116]. These two kinases play a key role in many pathophysiological processes, such as mitochondrial biogenesis... Many works have demonstrated that polyphenols are able to modulate SIRT1 and that this activity is related to the increase of AMPK and the decrease of mTOR signaling [117].
Why this rating
Review paper citing in vitro and animal studies; human clinical data is limited or mixed.
Source
Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging
Carolina Simioni et al. · Oncotarget · 2018
narrative_reviewCited 511×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →