Research

Mixed

Adherence to a Mediterranean diet supplemented with extra-virgin olive oil (EVOO) significantly reduces the incidence of invasive breast cancer in postmenopausal women at high cardiovascular risk compared to a control low-fat diet.

If you are a postmenopausal woman with cardiovascular risk factors, incorporating extra-virgin olive oil as a primary fat source (aiming for roughly 1 liter per week distributed across your meals) into a Mediterranean-style diet may significantly lower your risk of developing invasive breast cancer. This benefit appears driven by the polyphenols and monounsaturated fats in the oil, rather than just calorie reduction. Focus on high-quality EVOO and use it to replace saturated fats, rather than adding it on top of an already high-fat diet.

GoodSupportsHIGH confidence
This is the first randomized trial finding an effect of a long-term dietary intervention on breast cancer incidence. Our results suggest a beneficial effect of a Mediterranean diet supplemented with extra-virgin olive oil in the primary prevention of breast cancer.
Estefanía Toledo et al. · JAMA Internal Medicine · 2015

Why this rating

Randomized controlled trial design with blinded outcome assessment, but limited by a small number of incident cases (n=35) and relatively short follow-up (median 4.8 years).

Source

Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial

Estefanía Toledo et al. · JAMA Internal Medicine · 2015

DOI 10.1001/jamainternmed.2015.4838

rct · n=4282Cited 510×
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DOI resolved against Crossref · corpus check 2026-06-10

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