Research

Mixed

The gut microbiome of healthy Japanese individuals exhibits a distinct functional profile characterized by high abundance of Actinobacteria (specifically Bifidobacterium) and a unique hydrogen metabolism pathway that favors acetogenesis over methanogenesis, which cannot be fully explained by diet alone.

This research highlights that gut microbiomes are population-specific and influenced by factors beyond just what you eat today. For Japanese individuals, a high abundance of Bifidobacterium and a preference for acetogenesis (producing acetate) over methanogenesis (producing methane) are characteristic. These features may contribute to health benefits like lower inflammation and longer lifespan, but they are deeply rooted in population-level adaptations, not just short-term dietary changes.

GoodSupportsHIGH confidence
We found that the composition of the Japanese gut microbiome showed more abundant in the phylum Actinobacteria, in particular in the genus Bifidobacterium, than other nations... The remarkable low prevalence of genes for methanogenesis with a significant depletion of the archaeon Methanobrevibacter smithii and enrichment of acetogenesis genes in the Japanese gut microbiome compared with others suggested a difference in the hydrogen metabolism pathway in the gut between them.
Suguru Nishijima et al. · DNA Research · 2016

Why this rating

Large sample size (n=106 Japanese, n=755 others), rigorous metagenomic sequencing, and statistical validation, though it is an observational cross-sectional study.

Source

The gut microbiome of healthy Japanese and its microbial and functional uniqueness

Suguru Nishijima et al. · DNA Research · 2016

DOI 10.1093/dnares/dsw002

cross_sectional · n=861Cited 510×
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DOI resolved against Crossref · corpus check 2026-06-10

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