Hormonal
Menopausal Hormone Therapy (MHT) is associated with lower epigenetic age acceleration in buccal epithelium, suggesting a potential protective effect against epigenetic aging in this tissue.
This study found that women using Menopausal Hormone Therapy (MHT) had lower epigenetic age in their cheek cells (buccal epithelium) compared to non-users. This suggests MHT might help slow biological aging in this specific tissue. However, this effect was not seen in blood, so the overall benefit is complex. Discuss the potential benefits and risks of MHT with your healthcare provider.
a lower epigenetic age in buccal epithelium was found for women who underwent menopausal hormone therapy (P = 0.00078).
Why this rating
Statistically significant association (P=0.00078) in a large cohort (NSHD), but limited to one tissue type.
Source
Menopause accelerates biological aging
Morgan E. Levine et al. · Proceedings of the National Academy of Sciences · 2016
DOI 10.1073/pnas.1604558113
More from this paper
- Menopause, particularly when occurring early or via surgical removal of ovaries, accelerates biological aging as measured by epigenetic age acceleration in blood.Good
- Surgical menopause (bilateral oophorectomy) before age 50 is associated with increased epigenetic age acceleration in both blood and saliva.Good
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