Macro partitioning

Saturated fatty acids (SFAs) are more hepatotoxic than unsaturated fatty acids (UFAs) because they induce ER stress, oxidative stress, and apoptosis more effectively.

Not all fats affect the liver equally. Saturated fats are more likely to cause liver damage and inflammation than unsaturated fats. Reducing saturated fat intake may help mitigate liver stress in NAFLD patients.

GoodSupportsHIGH confidence

Saturated FFAs are more hepatotoxic than unsaturated species. In vitro studies demonstrated that monounsaturated palmitoleate (POA) (C16:1) and oleate (OA) (C18:1) are less toxic than saturated FFAs such as (C18:0) or stearate (SA) (C16:0).

Patricia Rada et al. · Cell Death and Disease · 2020

Why this rating

Supported by multiple in vitro and animal studies cited.

Source

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

Patricia Rada et al. · Cell Death and Disease · 2020

narrative_reviewCited 496×

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