Hormonal
In obese individuals, higher physical activity levels are associated with significantly lower serum concentrations of specific anti-inflammatory cytokines (IL-10, IL-13) and pro-inflammatory cytokines (IL-2, IL-12, IFN-γ, TNF-α), independent of BMI.
If you have obesity, increasing your daily physical activity (measured by steps or energy expenditure) is associated with lower levels of key inflammatory markers in your blood, even if your weight doesn't change immediately. Focus on consistent movement to help modulate your immune response.
In participants with general obesity, levels of IL-4, IL-10 and IL-13 were significantly elevated in participants with low physical activity, even when controlled for BMI which was negatively associated with physical acitivity.
Why this rating
Cross-sectional study design limits causal inference, though the sample size (n=200) and objective actigraphy measures are strengths.
Source
Inflammatory Cytokines in General and Central Obesity and Modulating Effects of Physical Activity
Frank Schmidt et al. · PLoS ONE · 2015
DOI 10.1371/journal.pone.0121971
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