Energy balance
Orlistat (120 mg TID) combined with caloric restriction does not provide superior weight loss or histological improvement in NASH patients compared to caloric restriction and vitamin E alone.
If you have NASH, taking orlistat along with a strict low-calorie diet and vitamin E will not improve your liver health or help you lose more weight than just following the diet and taking vitamin E alone. The key to improving your liver is achieving significant weight loss (at least 9%), regardless of whether you use the medication.
Orlistat did not enhance weight loss or improve liver enzymes, measures of insulin resistance, and histopathology.
Why this rating
Randomized, prospective trial with biopsy endpoints, though limited by open-label design and small sample size (n=41 completed).
Source
Orlistat for overweight subjects with nonalcoholic steatohepatitis
Stephen A. Harrison et al. · Hepatology · 2008
DOI 10.1002/hep.22575
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