Hormonal
GDF-15 acts as a metabolic regulator that decreases food intake, body weight, and adiposity, and improves glucose tolerance, suggesting a potential therapeutic target for obesity and insulin resistance.
While GDF-15 naturally helps regulate weight and glucose, there are no approved GDF-15 supplements or treatments for weight loss yet. Focus on natural ways to support metabolic health: regular exercise, adequate sleep, and a balanced diet, which help regulate your body's natural stress responses and hormone levels.
Recently Macia et al. found that GDF-15 decreases food intake, body weight, and adiposity and improves glucose tolerance in normal and obesogenic diets
Why this rating
Based on animal models (Macia et al.) and observational human studies; therapeutic application is still experimental.
Source
GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective
Ramu Adela et al. · Journal of Diabetes Research · 2015
DOI 10.1155/2015/490842
More from this paper
- Elevated circulating levels of Growth Differentiation Factor-15 (GDF-15) serve as a robust prognostic biomarker for cardiovascular mortality, heart failure severity, and all-cause mortality in patients with diabetes and cardiovascular diseases.Good
- GDF-15 exhibits a dual role in cardiovascular health: it is cardioprotective against ischemia and hypertrophy via Smad and PI3K/AKT pathways, but its chronic elevation is associated with the progression of atherosclerosis and plaque instability.Good
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