Research
Hormonal
Macrophage infiltration into adipose tissue is a primary mechanism by which obesity causes insulin resistance.
Reducing the accumulation of immune cells (macrophages) in fat tissue may improve insulin sensitivity. This suggests that anti-inflammatory strategies could be beneficial for metabolic health in obesity.
GoodSupportsHIGH confidence
The central role of macrophages in mediating obesity-associated insulin resistance is best demonstrated by the numerous genetic studies targeting macrophages and macrophage signaling which ameliorate or exacerbate the insulin-resistant state.
Why this rating
Strong evidence from genetic knockout and pharmacological intervention studies in mice.
Source
Energy Balance and Obesity
James O. Hill et al. · Circulation · 2012
DOI 10.1161/circulationaha.111.087213
book_chapterCited 1,287×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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