Research
Micronutrients & recovery
Omega-3 fatty acids improve insulin sensitivity by activating the GPR120 receptor on macrophages, thereby reducing adipose tissue inflammation.
Consuming omega-3 fatty acids may help reduce inflammation in fat tissue and improve insulin sensitivity, but this benefit depends on having a functional GPR120 receptor. Individuals with specific genetic variants of this receptor may not receive the same metabolic benefits.
ModerateSupportsMEDIUM confidence
GPR120 is a receptor for anti-inflammatory, omega-3 fatty acids. Omega-3 fatty acids inhibit macrophage chemotaxis, ameliorate adipose tissue inflammation, and enhance insulin sensitivity in a GPR120-dependent manner indicating that this is a potent anti-inflammatory pathway in vivo.
Why this rating
Evidence is primarily from mouse models (DIO mice) and genetic polymorphism studies in humans.
Source
Energy Balance and Obesity
James O. Hill et al. · Circulation · 2012
DOI 10.1161/circulationaha.111.087213
book_chapterCited 1,287×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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