Research
Macro partitioning
High intake of trans-fatty acids and foods with a high glycemic index or load significantly increases the risk of coronary heart disease.
Limit intake of trans-fatty acids and foods with a high glycemic index or load, as higher consumption is strongly associated with an increased risk of coronary heart disease.
StrongSupportsHIGH confidence
Strong evidence supports valid associations... of harmful factors, including intake of trans–fatty acids and foods with a high glycemic index or load.
Why this rating
Score of 4/4 Bradford Hill criteria.
Source
A Systematic Review of the Evidence Supporting a Causal Link Between Dietary Factors and Coronary Heart Disease
Andrew Mente et al. · Archives of Internal Medicine · 2009
DOI 10.1001/archinternmed.2009.38
Meta-analysis · 189 studiesCited 1,280×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
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- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
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