Research
Hormonal
Pioglitazone and Vitamin E are beneficial pharmacological interventions for non-diabetic NASH patients, and Pioglitazone improves fibrosis in diabetic patients.
For non-diabetic NASH, Pioglitazone or Vitamin E may be beneficial. For diabetic patients, Pioglitazone has been shown to reverse NASH and improve fibrosis. Consult a physician for prescription options.
GoodQualifiesHIGH confidence
Prior clinical trial data suggest that pioglitazone or vitamin E may be beneficial in non-diabetic NASH patients [38] and the benefit of pioglitazone on reversing NASH and improving fibrosis was recently confirmed in diabetic patients [39].
Why this rating
Cited clinical trials support efficacy in specific subgroups.
Source
Non-alcoholic fatty liver disease
Brent A. Neuschwander‐Tetri · BMC Medicine · 2017
DOI 10.1186/s12916-017-0806-8
narrative_reviewCited 462×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Lifestyle modification focusing on weight loss and exercise is the primary effective therapy for reversing features of non-alcoholic steatohepatitis (NASH) and fibrosis.Good
- Elafibranor (PPAR alpha/delta agonist) and Obeticholic Acid (FXR ligand) show promise in resolving NASH and improving fibrosis in clinical trials.Moderate
- Liraglutide (GLP-1 analogue) barely met the primary endpoint for NASH resolution in a small trial, while Sitagliptin showed no effect on liver histology.Moderate
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