Research
Energy balance
Lifestyle modification focusing on weight loss and exercise is the primary effective therapy for reversing features of non-alcoholic steatohepatitis (NASH) and fibrosis.
Focus on sustainable weight loss and regular physical activity. Adopting a Mediterranean-style diet and increasing exercise are the most proven ways to reverse liver inflammation and fibrosis in NAFLD patients. This is the first-line treatment before considering medications.
GoodSupportsHIGH confidence
Lifestyle modification with a focus on healthy eating, weight loss when needed, and regular exercise remain the cornerstone of therapy in adults [28–31] and children [32].
Why this rating
Supported by multiple cited studies (28-32) showing significant reduction in NASH features, though specific pooled effect sizes are not detailed in this review text.
Source
Non-alcoholic fatty liver disease
Brent A. Neuschwander‐Tetri · BMC Medicine · 2017
DOI 10.1186/s12916-017-0806-8
narrative_reviewCited 462×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Pioglitazone and Vitamin E are beneficial pharmacological interventions for non-diabetic NASH patients, and Pioglitazone improves fibrosis in diabetic patients.Good
- Elafibranor (PPAR alpha/delta agonist) and Obeticholic Acid (FXR ligand) show promise in resolving NASH and improving fibrosis in clinical trials.Moderate
- Liraglutide (GLP-1 analogue) barely met the primary endpoint for NASH resolution in a small trial, while Sitagliptin showed no effect on liver histology.Moderate
Related findings · Energy balance
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