Hormonal
17-alpha-estradiol extends median lifespan in male mice, with effects varying significantly by testing site, but has no effect on female lifespan.
17-alpha-estradiol, a nonfeminizing estrogen, extended the lifespan of male mice by 12% on average, though results varied by location. It had no effect on female lifespan. This suggests that specific estrogenic pathways might be targeted for male longevity without causing feminization.
EST increased male median lifespan by 12% (P = 0.002), but did not lead to a significant effect on maximum lifespan. ... EST did not alter female lifespan.
Why this rating
Statistically significant pooled result (P=0.002), but site-specific variability (strong at UT, non-significant at TJL/UM) reduces confidence.
Source
Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
David E. Harrison et al. · Aging Cell · 2013
DOI 10.1111/acel.12170
More from this paper
- Acarbose extends median lifespan in male mice significantly more than in female mice, despite reducing body weight more in females.Good
- Nordihydroguaiaretic acid (NDGA) extends median lifespan in male mice across multiple doses, but has no effect on female lifespan even when blood levels are matched to males.Good
- Methylene blue does not significantly extend median lifespan in male or female mice, but significantly increases maximum lifespan (90th percentile) in females.Moderate
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