Research
Energy balance
Caloric restriction extends lifespan and delays age-related pathologies by activating autophagy and reducing inflammasome activation.
Caloric restriction is a proven way to extend lifespan and delay disease by activating your body's cleanup processes. While strict restriction is hard, finding a sustainable way to eat slightly less or practice intermittent fasting can mimic these benefits.
StrongSupportsVERY_HIGH confidence
Caloric restriction (CR) is the most common anti-aging intervention which can extend lifespan in organisms ranging from yeast to humans... CR is a potent physiological activator of autophagy.
Why this rating
Supported by extensive evidence across multiple species, including rhesus monkeys.
Source
Inflammaging: disturbed interplay between autophagy and inflammasomes
Antero Salminen et al. · Aging · 2012
DOI 10.18632/aging.100444
narrative_reviewCited 487×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Declining autophagic capacity during aging leads to the accumulation of dysfunctional mitochondria and aggregated proteins, which triggers NLRP3 inflammasome activation and chronic low-grade inflammation (inflammaging).Good
- Pharmacological activation of autophagy using mTOR inhibitors (e.g., rapamycin) or AMPK activators (e.g., metformin, AICAR) can extend lifespan and reduce inflammation in animal models.Good
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