Research
Energy balance
Hypoxia in white adipose tissue increases glucose utilization by upregulating GLUT1 expression and protein levels, enhancing glucose transport in human adipocytes.
Hypoxia forces fat cells to consume more glucose via GLUT1 transporters. This metabolic shift is part of the dysregulation seen in obesity but does not currently suggest a direct therapeutic intervention for weight loss.
GoodSupportsHIGH confidence
GLUT1 gene expression, protein level and glucose transport by human adipocytes are markedly increased by hypoxia, indicating that low O2 tension stimulates glucose utilisation.
Why this rating
Supported by cell culture studies showing increased GLUT1 and functional glucose uptake.
Source
Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
Paul Trayhurn et al. · British Journal Of Nutrition · 2008
DOI 10.1017/s0007114508971282
narrative_reviewCited 460×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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