Hormonal
Failure of adipose tissue to expand via new fat cell formation (proliferation/differentiation) forces excess lipid into ectopic sites (liver, skeletal muscle, pancreas), causing insulin resistance and type 2 diabetes.
Your body's ability to safely store fat in your fat cells is a key factor in your metabolic health. If your fat cells can't grow or multiply enough to handle your energy intake, fat spills over into your liver and muscles, causing insulin resistance. Focus on maintaining a healthy weight and metabolic health rather than just fearing fat, as the *capacity* to store fat safely matters immensely.
failure to develop adequate adipose tissue mass in either mice or humans, also known as lipodystrophy, results in severe insulin resistance and diabetes. This is thought to be the result of ectopic storage of lipid into liver, skeletal muscle, and the pancreatic insulin-secreting beta cell.
Why this rating
Supported by multiple lines of evidence including human lipodystrophy, transgenic animal models, and human imaging studies correlating muscle/liver fat with insulin resistance.
Source
Increased Fat Intake, Impaired Fat Oxidation, and Failure of Fat Cell Proliferation Result in Ectopic Fat Storage, Insulin Resistance, and Type 2 Diabetes Mellitus
Éric Ravussin et al. · Annals of the New York Academy of Sciences · 2002
DOI 10.1111/j.1749-6632.2002.tb04292.x
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