Hormonal
In aged muscle, mTORC1 is hyperphosphorylated but fails to induce protein synthesis effectively, leading to anabolic resistance and contributing to sarcopenia.
As you age, your muscles become 'anabolically resistant,' meaning standard training might not trigger muscle growth as efficiently. Your mTOR pathway may be 'stuck' in a state that doesn't effectively build protein. To counter this, older adults may need to focus on high-intensity resistance training and adequate protein intake to overcome this resistance and maintain muscle mass.
the hyperactivation of mTOR in aged muscles does not induce protein synthesis... Chronic mTORC1 activation through TSC1 knockout in old muscle leads to muscle atrophy mainly due to inability to induce autophagy
Why this rating
Review of multiple studies showing inconsistent IGF-1/mTOR correlation in aging but consistent hyperphosphorylation without synthesis.
Source
mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass
Mee‐Sup Yoon · Frontiers in Physiology · 2017
DOI 10.3389/fphys.2017.00788
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