Hormonal

Gut microbiota promotes diet-induced obesity and hepatic steatosis through Farnesoid X Receptor (FXR) signaling; FXR deficiency or inhibition alters bile acid profiles to suppress this pathway, resulting in reduced adiposity and improved glucose metabolism.

Your gut bacteria play an active role in how your body processes fat and stores energy, specifically through a receptor called FXR. While this research is in mice, it suggests that maintaining a diverse microbiota and avoiding factors that disrupt bile acid signaling (like excessive antibiotic use or specific dietary patterns that alter bile acids) may support metabolic health. Focus on whole foods that support microbial diversity rather than just calorie counting.