Research
Mixed
Transplanting gut microbiota from FXR-deficient mice into germ-free wild-type mice transfers a leaner phenotype and improved glucose tolerance, demonstrating that the microbiota composition itself is a transmissible factor for metabolic health.
The specific types of bacteria in your gut can influence your weight and blood sugar control. While this study used mice, it highlights that a 'lean' microbiome profile can be transferred. You can support a healthy microbiome by eating a variety of fiber-rich plants, which feed beneficial bacteria that may help regulate metabolism.
GoodSupportsHIGH confidence
By transferring the caecal microbiota from HFD-fed Fxr-/- and wild-type mice into GF mice, we showed that the obesity phenotype was transferable.
Why this rating
Strong experimental design using fecal microbiota transplantation (FMT) in mice.
Source
Microbiota-induced obesity requires farnesoid X receptor
Ava Parséus et al. · Gut · 2016
DOI 10.1136/gutjnl-2015-310283
mechanism_onlyCited 456×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Mixed
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