Adherence
Leptin regulates body weight in humans predominantly by affecting eating behavior (satiety) rather than by increasing energy expenditure (calorigenesis).
Unlike in mice, where leptin increases energy expenditure, in humans, high leptin levels do not correlate with higher energy expenditure. This suggests that leptin's primary role in weight regulation is through satiety and eating behavior, not by burning more calories at rest.
The observation that serum leptin is not related to energy expenditure rates suggests that leptin regulates body fat predominantly by altering eating behavior rather than calorigenesis.
Why this rating
Based on the absence of correlation with energy expenditure, which is an indirect inference rather than a direct measurement of eating behavior.
Source
The Metabolic Significance of Leptin in Humans: Gender-Based Differences in Relationship to Adiposity, Insulin Sensitivity, and Energy Expenditure*
Adele Kennedy et al. · The Journal of Clinical Endocrinology & Metabolism · 1997
DOI 10.1210/jcem.82.4.3859
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