Hormonal
Long-term consumption of diets high in fat and/or fructose attenuates insulin and leptin production, leading to increased energy intake and contributing to weight gain and obesity.
If you eat a lot of fat and sugar, your body may produce less of the hormones (insulin and leptin) that tell your brain you are full and have enough energy. This can make you hungrier and lead to weight gain over time. It is not just about 'spiking' insulin with carbs, but how your long-term diet affects these hormonal signals.
Dietary fat and fructose do not stimulate Insulin secretion and leptln production. Therefore, attenuated production of Insulin and leptln could lead to In-creased energy Intake and contribute to weight gain and obe-sity during long-term consumption of diets high In fat and/or fructose.
Why this rating
The paper is a comprehensive review citing multiple animal and human studies, though it does not present new primary data itself.
Source
Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis
Peter J. Havel · Experimental Biology and Medicine · 2001
DOI 10.1177/153537020122601102
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