Hormonal
Short-term satiety signals (like CCK and glucose) are insufficient to regulate long-term body adiposity and can be overridden by long-term regulators (insulin and leptin).
Feeling full from a meal doesn't guarantee you won't gain weight long-term. Your body uses long-term hormones like leptin and insulin to set your 'weight thermostat.' If your diet disrupts these hormones, you might feel full but still gain weight because your brain isn't getting the long-term signal that you have enough energy stores.
However, the energy density of food and short-term hormonal signals by themselves are Insufficient to produce sustained changes In energy balance and body adiposity. Rather, these signals interact with long-term regulators (i.e., Insulin, leptln, and possibly the orexigenlc gastric peptide, ghrelln) to maintain energy homeostasis.
Why this rating
Well-supported by the review of multiple studies on CCK, glucose, and leptin.
Source
Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis
Peter J. Havel · Experimental Biology and Medicine · 2001
DOI 10.1177/153537020122601102
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