Hormonal
Higher endogenous total testosterone (TT) and sex hormone-binding globulin (SHBG) levels are independently associated with a reduced risk of metabolic syndrome and higher insulin sensitivity in aging men.
For aging men, maintaining higher endogenous testosterone and SHBG levels is linked to a lower risk of metabolic syndrome and better insulin sensitivity. While this study is observational and does not prove that boosting testosterone causes health improvements, it highlights that low levels are a marker of metabolic risk. Focus on lifestyle factors known to support healthy hormone levels, such as resistance training, adequate sleep, and maintaining a healthy body composition, rather than seeking unproven interventions.
Higher testosterone and SHBG levels in aging males are independently associated with a higher insulin sensitivity and a reduced risk of the metabolic syndrome, independent of insulin levels and body composition measurements, suggesting that these hormones may protect against the development of metabolic syndrome.
Why this rating
Cross-sectional design limits causal inference, but the sample size is large (n=400) and adjustments for confounders are robust.
Source
Endogenous Sex Hormones and Metabolic Syndrome in Aging Men
Majon Muller et al. · The Journal of Clinical Endocrinology & Metabolism · 2005
DOI 10.1210/jc.2004-1158
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