Hormonal
Higher endogenous estradiol (E2) levels are not significantly associated with the risk of metabolic syndrome in aging men, although they are associated with specific risk factors like waist circumference and triglycerides.
In aging men, higher estradiol levels do not appear to protect against metabolic syndrome, nor do they significantly increase the overall risk. However, higher E2 is linked to increased waist circumference and triglycerides. Focus on overall metabolic health through diet and exercise rather than targeting estradiol levels specifically, as the relationship is complex and not protective for the syndrome as a whole.
Each SD increase in E2 levels was not significantly associated with the metabolic syndrome (OR = 1.16; 95% CI, 0.92–1.45).
Why this rating
Consistent with the cross-sectional design; the lack of association with the composite syndrome is clear, but associations with components exist.
Source
Endogenous Sex Hormones and Metabolic Syndrome in Aging Men
Majon Muller et al. · The Journal of Clinical Endocrinology & Metabolism · 2005
DOI 10.1210/jc.2004-1158
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