Energy balance
Treatment with Bone Morphogenetic Protein 7 (BMP7) induces tissue-resident progenitor cells in skeletal muscle and subcutaneous white fat to differentiate into brown adipocytes expressing UCP1, thereby increasing energy expenditure.
This research identifies a specific protein (BMP7) that can turn fat-storing cells in your muscles and subcutaneous fat into energy-burning brown fat cells. While this is currently a laboratory finding in mice and cell cultures, it suggests that future therapies might target these specific progenitor cells to treat obesity by increasing your body's natural energy expenditure.
Sca-1+ cells from skeletal muscle and subcutaneous white fat are highly inducible to differentiate into brown-like adipocytes upon stimulation with bone morphogenetic protein 7 (BMP7).
Why this rating
The study is conducted on murine models and ex vivo human cells; in vivo human data is not provided.
Source
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
Tim J. Schulz et al. · Proceedings of the National Academy of Sciences · 2010
DOI 10.1073/pnas.1010929108
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