Micronutrients & recovery
Monthly high-dose vitamin D3 supplementation (200,000 IU initial, then 100,000 IU monthly) does not prevent cardiovascular disease in the general population.
Taking 100,000 IU of Vitamin D3 once a month will not prevent heart disease or stroke, even if you are deficient. While maintaining adequate Vitamin D levels is important for bone health, this specific high-dose monthly regimen has not been shown to reduce cardiovascular risk in older adults. Do not use Vitamin D as a substitute for standard cardiovascular prevention strategies.
Monthly high-dose vitamin D supplementation does not prevent CVD. This result does not support the use of monthly vitamin D supplementation for this purpose.
Why this rating
Large-scale (n=5108), randomized, double-blind, placebo-controlled trial with high adherence and long follow-up (median 3.3 years).
Source
Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study
Robert Scragg et al. · JAMA Cardiology · 2017
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