Research
Hormonal
Inhibition of ceramide synthesis improves glucose and energy metabolism by recovering insulin signaling in liver and muscle.
While direct ceramide inhibitors like myriocin show promise in research, they are not currently standard human treatments. Focus on reducing saturated fat intake to naturally lower ceramide levels.
ModerateSupportsMEDIUM confidence
Furthermore, inhibition of ceramide synthesis via myriocin treatment improves glucose and energy metabolism via recovery of insulin signaling in liver and muscle (29).
Why this rating
Based on a single cited study using a pharmacological inhibitor (myriocin) in models.
Source
Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment
Meric Erikci Ertunc et al. · Journal of Lipid Research · 2016
DOI 10.1194/jlr.r066514
narrative_reviewCited 480×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Chronic nutrient excess and obesity overwhelm adipose tissue storage capacity, causing ectopic lipid accumulation in liver and muscle, which triggers lipotoxicity and metaflammation, leading to insulin resistance and metabolic disease.Good
- Saturated fatty acids (e.g., palmitate) and oxidized cholesterol drive metaflammation by activating stress kinases (JNK, PKC, PKR) and inflammatory pathways (TLR4, NF-kB), which directly inhibit insulin signaling.Good
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