Research
Hormonal
Endogenous satiation signals (like CCK) are subservient to long-term adiposity signals (leptin/insulin) and cannot cause long-term weight loss in free-feeding animals because they compensate by eating more frequently.
Your body's natural 'fullness' signals (like CCK) are not strong enough to keep you thin if you are genetically prone to obesity, because your body will just make you eat more often to compensate. This is why willpower alone often fails.
GoodRefutesHIGH confidence
Moreover, the effect of repeated or chronic administration of CCK... has no effect on body weight because the short-term regulation of meal size is overridden by overall energy balance.
Why this rating
Supported by animal studies cited in the review.
Source
Central Control of Body Weight and Appetite
Stephen C. Woods et al. · The Journal of Clinical Endocrinology & Metabolism · 2008
DOI 10.1210/jc.2008-1630
narrative_reviewCited 450×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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