Research
Hormonal
Obese individuals have attenuated postprandial secretion of satiation signals like PYY and GLP-1 compared to lean individuals, which may contribute to obesity.
If you are obese, your body may naturally produce less of the 'fullness' hormones (like PYY) after eating compared to lean people. This is a biological factor, not just a lack of willpower.
GoodSupportsHIGH confidence
Fasting and postprandial levels of PYY are lower in obese adults compared with lean controls... The attenuated rise in PYY after eating has also been observed in obese adolescents.
Why this rating
Based on human studies comparing obese and lean cohorts.
Source
Central Control of Body Weight and Appetite
Stephen C. Woods et al. · The Journal of Clinical Endocrinology & Metabolism · 2008
DOI 10.1210/jc.2008-1630
narrative_reviewCited 450×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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