Energy balance
Skeletal muscle inactivity (sedentary behavior) downregulates genes involved in mitochondrial processes and ATP production, while acute exercise upregulates these pathways, with NR4A3 serving as a key regulator of this metabolic response.
Sedentary time actively suppresses your muscles' ability to produce energy (mitochondrial function). While exercise boosts this, the key takeaway is that prolonged inactivity reverses these benefits. To maintain metabolic health, avoid long periods of sitting, as inactivity actively downregulates the genes responsible for energy production.
Inactivity was associated with a reduction in the expression of genes involved in mitochondrial processes and ATP production... Conversely, aerobic training triggered an increase in mRNA of genes related to metabolic pathways and mitochondrial function... These results establish a role for NR4A3 in regulating the metabolic response to exercise.
Why this rating
High-quality meta-analysis of 66 datasets (n>1100) combined with in vitro validation, though clinical translation of NR4A3 modulation is not yet established.
Source
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
Nicolas J. Pillon et al. · Nature Communications · 2020
DOI 10.1038/s41467-019-13869-w
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