Research
Hormonal
RYGB surgery increases faecal GABA and glutamate, which may stimulate GLP-1 release and contribute to metabolic enhancement and weight loss.
Surgery increases gut bacteria that produce GABA, which may help stimulate hormones that reduce appetite and improve blood sugar control.
ModerateSupportsMEDIUM confidence
A surgically-induced effect on the gut-brain-liver metabolic axis is inferred by increased neurotropic compounds; faecal γ-aminobutyric acid (GABA) and glutamate.
Why this rating
Based on rat model data; human relevance is inferred.
Source
Metabolic surgery profoundly influences gut microbial–host metabolic cross-talk
Jia V. Li et al. · Gut · 2011
DOI 10.1136/gut.2010.234708
mechanism_only · n=29Cited 446×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Roux-en-Y gastric bypass (RYGB) surgery induces a profound shift in gut microbiota, specifically a 52-fold increase in Proteobacteria (notably Enterobacter hormaechei) and a decrease in Firmicutes, which correlates with weight loss and metabolic enhancement.Moderate
- RYGB surgery leads to decreased faecal bile acids and altered energy metabolism, including decreased urinary succinate, 2-oxoglutarate, citrate, and fumarate, indicating modulated mitochondrial function.Moderate
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