Energy balance
Exercise training reduces the exercise-induced activation of AMPK in skeletal muscle, primarily due to a significant decrease (10-60%) in AMPKgamma3 protein content and potentially elevated glycogen levels.
As you become fitter, your muscle's acute AMPK response to the same workout will decrease. This is not a failure; it indicates improved energy homeostasis and efficiency. This reduction is largely driven by a 10-60% drop in AMPKgamma3 protein content. Do not interpret this reduced molecular signaling as a lack of training effect.
Several studies have shown that activation of skeletal muscle AMPK by acute exercise, performed at the same absolute and relative intensity, is reduced after a period of exercise training... Another factor could be the striking decrease in AMPKgamma3 protein content (10-60%) observed in skeletal muscle after exercise training... Because the AMPK alpha2beta2gamma3 complex is the major complex activated in skeletal muscle during exercise, it would indeed be expected that the exercise-induced activation of AMPK is affected by a reduction in AMPKgamma3 protein content after exercise training.
Why this rating
The paper cites multiple studies (refs 69, 101, 110, 130, 131, 135) showing the reduction in gamma3 content and AMPK activation post-training.
Source
AMPK in skeletal muscle function and metabolism
Rasmus Kjøbsted et al. · The FASEB Journal · 2017
DOI 10.1096/fj.201700442r
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- Skeletal muscle AMPK activation during exercise is strictly dependent on exercise intensity and duration, with high-intensity/short-duration exercise activating alpha2beta2gamma3 complexes via LKB1, while low-intensity/long-duration exercise activates alpha2beta2gamma1 and alpha1beta2gamma1 complexes via CaMKKbeta.Good
- Pharmacological activation of AMPK in skeletal muscle promotes glucose transport and fatty acid oxidation while suppressing glycogen synthase activity and protein synthesis.Good
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