Research
Hormonal
Galegine, isolated from Galega officinalis, has a chemical structure similar to metformin and is responsible for the blood glucose-lowering effects of the plant extract.
Galegine is the active compound in Goat's Rue that resembles Metformin, explaining why this plant has been used historically to treat diabetes.
ModerateSupportsMEDIUM confidence
From this plant, also called goat's rue, French lilac, or Italian fitch, a guanidine derivative, galegine, was isolated. This compound, whose chemical structure is quite similar to the antidiabetic drug metformin, is responsible for the lowering of blood glucose produced by the plant extract.
Why this rating
It is a historical fact and structural observation, not a current clinical trial outcome.
Source
Natural Products for the Treatment of Type 2 Diabetes Mellitus
José Luis Rı́os et al. · Planta Medica · 2015
DOI 10.1055/s-0035-1546131
narrative_reviewCited 445×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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