Research
Mixed
ASCs exhibit multipotency, differentiating into mesenchymal (adipocytes, osteoblasts, chondrocytes) and non-mesenchymal (neural, endothelial) cell types, though their in vivo functional capacity varies by tissue source and context.
ASCs are versatile and can become many cell types, making them valuable for regenerative medicine. However, their effectiveness in vivo is complex and depends on how they are isolated and used.
GoodSupportsHIGH confidence
Such adipose tissue-derived stem cells (ASCs) are capable of differentiating into numerous cell types of both mesodermal and nonmesodermal origin, leading to their extensive investigation from a therapeutic and tissue engineering perspective.
Why this rating
Based on extensive in vitro and in vivo studies (Table 2).
Source
Adipose tissue stem cells meet preadipocyte commitment: going back to the future
William P. Cawthorn et al. · Journal of Lipid Research · 2011
DOI 10.1194/jlr.r021089
narrative_reviewCited 443×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- White adipose tissue (WAT) maintains adipocyte numbers through continuous renewal by committed preadipocytes (hyperplasia) rather than solely through hypertrophy of existing cells, with approximately 10% of adipocytes renewed annually.Good
- Adipose tissue-derived stem cells (ASCs) are perivascular cells (pericytes) located around blood vessels, characterized by specific surface markers such as CD146+, NG2+, and alpha-smooth muscle actin (alpha-SMA+).Good
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