Research
Energy balance
Caloric restriction extends lifespan and delays aging in mammals, partly through mechanisms involving autophagy and Sirt1 activation.
Caloric restriction is a proven strategy to extend lifespan and improve heart health in animal models, likely by activating autophagy and Sirt1. While specific dosing varies, reducing caloric intake is a key lever for longevity.
StrongSupportsVERY_HIGH confidence
Sirtuins are a family of 7 NAD+-dependent protein deacetylases known to be involved throughout the evolutionary tree in lifespan extension in response to caloric restriction (CR) and resveratrol... Sirt1... promotes autophagy through deacetylation and stimulation of Forkhead box O (FoxO) 1 in cardiomyocytes.
Why this rating
Extensively studied across multiple species.
Source
Aging and Autophagy in the Heart
Akihiro Shirakabe et al. · Circulation Research · 2016
DOI 10.1161/circresaha.116.307474
narrative_reviewCited 442×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Autophagy is downregulated in the aging heart, and this suppression contributes to cardiac pathology by allowing the accumulation of misfolded proteins and dysfunctional mitochondria.Good
- Stimulation of autophagy improves cardiac function in aging hearts by removing accumulated misfolded proteins and dysfunctional mitochondria.Good
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