Hormonal
Central fat distribution (waist circumference and waist-to-hip ratio) is an independent negative predictor of serum adiponectin levels, stronger than overall adiposity (BMI or total fat mass).
If you want to support healthy adiponectin levels, focus on reducing abdominal fat (waist circumference) rather than just total body weight. Central fat is a stronger determinant of low adiponectin than overall obesity.
Our cross-sectional study shows that, in addition to overall obesity, central fat distribution is an independent negative predictor of serum adiponectin...
Why this rating
Large cross-sectional study (n=121) with multivariate regression controlling for confounders.
Source
Serum Adiponectin Levels Are Inversely Associated with Overall and Central Fat Distribution but Are Not Directly Regulated by Acute Fasting or Leptin Administration in Humans: Cross-Sectional and Interventional Studies
Alina Gavrila et al. · The Journal of Clinical Endocrinology & Metabolism · 2003
DOI 10.1210/jc.2003-030214
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