Research
Hormonal
Serum estradiol is an independent negative predictor of serum adiponectin levels, explaining higher adiponectin in postmenopausal women compared to premenopausal women.
Lower estrogen levels (as seen in menopause) are associated with higher adiponectin. This is an independent factor from body fat.
GoodSupportsHIGH confidence
In addition, estradiol is negatively and independently associated with adiponectin...
Why this rating
Multivariate regression controlling for age, menopausal status, and body composition.
Source
Serum Adiponectin Levels Are Inversely Associated with Overall and Central Fat Distribution but Are Not Directly Regulated by Acute Fasting or Leptin Administration in Humans: Cross-Sectional and Interventional Studies
Alina Gavrila et al. · The Journal of Clinical Endocrinology & Metabolism · 2003
DOI 10.1210/jc.2003-030214
cross_sectional · n=144Cited 440×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Central fat distribution (waist circumference and waist-to-hip ratio) is an independent negative predictor of serum adiponectin levels, stronger than overall adiposity (BMI or total fat mass).Good
- Acute fasting (48 hours) and leptin administration (physiological or pharmacological doses) do not alter serum adiponectin levels in healthy humans.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →