Mixed
Higher serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) are significantly associated with increased mortality risk and poorer physical and cognitive performance in elderly individuals, including those classified as 'successfully aging'.
Monitor inflammatory markers like IL-6 and CRP as part of a comprehensive geriatric assessment. While these are predictive, they reflect underlying 'inflammaging.' Focus on modifiable drivers of inflammation such as maintaining a healthy weight (avoiding both underweight and obesity), managing cardiovascular risk factors, and ensuring adequate nutrition, as these are linked to lower inflammatory burden and better functional outcomes in aging.
Longer survival was associated with lower concentrations of IL-6 and CRP not only in individuals with aging-related diseases/disability... but also in the successfully aging subgroup... Higher IL-6 and CRP levels were associated with poorer physical performance (lower ADL score) and poorer cognitive performance (lower MMSE score)
Why this rating
Large sample size (n>3000), longitudinal follow-up, and statistically significant hazard ratios after adjusting for confounders.
Source
Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study
Monika Puzianowska‐Kuźnicka et al. · Immunity & Ageing · 2016
DOI 10.1186/s12979-016-0076-x
Related findings · Mixed
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