Energy balance
Sustained modest weight loss (mean 9.4%) combined with regular physical activity (approx. 150 min/week) significantly improves liver enzymes (ALT), fasting insulin levels, and health-related quality of life in overweight patients with chronic liver disease.
For overweight individuals with chronic liver disease, achieving a modest weight loss of around 5-10% through a caloric deficit and maintaining approximately 150 minutes of moderate aerobic exercise per week can significantly improve liver health markers (like ALT and insulin) and quality of life. The key to long-term success is avoiding extreme initial efforts and focusing on sustainable, moderate physical activity levels.
In summary, these findings demonstrate that maintenance of weight loss and exercise in overweight patients with liver disease results in a sustained improvement in liver enzymes, serum insulin levels, and quality of life.
Why this rating
Randomized controlled trial design with a 15-month follow-up, though the sample size is modest (n=31 completers) and includes mixed liver disease etiologies.
Source
Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life
Ingrid J. Hickman et al. · Gut · 2004
DOI 10.1136/gut.2003.027581
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