Hormonal
Empiric vitamin D supplementation is recommended for children/adolescents (1-18 years), adults ≥75 years, pregnant individuals, and those with high-risk prediabetes to prevent specific adverse outcomes, whereas supplementation beyond Dietary Reference Intakes (DRI) is not recommended for healthy adults under 75.
If you are pregnant, over 75, have high-risk prediabetes, or are a child/teen, take daily vitamin D (typically 600-3500 IU depending on group) via food or supplements. If you are a healthy adult under 75, stick to the standard Dietary Reference Intake (600-800 IU) and do not test your levels or take extra doses, as there is no evidence it prevents disease in you.
The panel suggests empiric vitamin D supplementation for children and adolescents aged 1 to 18 years... for those aged 75 years and older... for those who are pregnant... and for those with high-risk prediabetes... The panel suggests against empiric vitamin D supplementation above the current DRI to lower the risk of disease in healthy adults younger than 75 years.
Why this rating
Based on GRADE methodology with moderate certainty (⊕⊕◯◯ or ⊕⊕⊕◯) for most recommendations, noting limitations in trial design.
Source
Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline
Marie B. Demay et al. · The Journal of Clinical Endocrinology & Metabolism · 2024
DOI 10.1210/clinem/dgae290
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