Macro partitioning
Higher carbohydrate intake is associated with a decreased Free Leptin Index (FLI), while higher dietary fat intake is associated with an increased FLI, independent of total energy and body fat.
The ratio of free leptin to its binding receptor (FLI) shifts based on what you eat. Eating more carbohydrates tends to lower this ratio, while eating more fat tends to raise it, even if your total calories and body fat stay the same.
free leptin index is negatively associated with energy intake from carbohydrates and positively with energy intake from dietary fat
Why this rating
Same cross-sectional design with strong confounder control. Causality remains unproven.
Source
Body Fat Mass and Macronutrient Intake in Relation to Circulating Soluble Leptin Receptor, Free Leptin Index, Adiponectin, and Resistin Concentrations in Healthy Humans
Mary Yannakoulia et al. · The Journal of Clinical Endocrinology & Metabolism · 2003
DOI 10.1210/jc.2002-021604
More from this paper
- In healthy young adults, higher carbohydrate intake is associated with increased soluble leptin receptor (sOB-R) concentrations, while higher dietary fat intake is associated with decreased sOB-R, independent of total energy intake and body fat mass.Good
- In healthy young adults, serum adiponectin and resistin concentrations are not significantly associated with total energy intake or macronutrient composition, after controlling for gender and body fat mass.Good
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