Hormonal
Chronic caloric surplus triggers a low-grade, chronic inflammatory state termed 'metaflammation' in metabolic tissues, which directly inhibits insulin signaling and promotes insulin resistance.
If you consistently eat more energy than you burn, your body doesn't just store fat; it starts sending inflammatory signals that block insulin. This 'metaflammation' makes it harder for your body to manage blood sugar and store energy efficiently. Reducing caloric surplus is the primary way to reduce this inflammatory burden and restore metabolic sensitivity.
Under conditions of nutritional excess, this integration can result in a metabolically driven, low-grade, chronic inflammatory state, referred to as 'metaflammation,' that targets metabolically critical organs and tissues to adversely affect systemic homeostasis.
Why this rating
The paper is a review citing numerous genetic and chemical studies in mice and human observational data, establishing strong mechanistic links.
Source
Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes
Sarah Hummasti et al. · Circulation Research · 2010
DOI 10.1161/circresaha.110.225698
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