Micronutrients & recovery
Saturated fatty acids (e.g., palmitate) activate inflammatory pathways via Toll-like receptors (TLRs) and Protein Kinase C (PKC) isoforms, leading to insulin resistance, whereas unsaturated fatty acids generally do not trigger this response.
The type of fat you eat matters for inflammation. Diets high in saturated fats (like those found in some animal products) can trigger inflammatory pathways that block insulin action. In contrast, unsaturated fats (like those in plants and fish) generally do not trigger this inflammatory response. Prioritizing unsaturated fats may help reduce metabolic inflammation.
Moreover, the nature of inflammatory responses depends on the specific FA involved, with saturated FAs generating a proinflammatory response but polyunsaturated FAs showing little or no inflammatory effect.
Why this rating
Supported by multiple studies cited in the review regarding FA composition and inflammatory outcomes.
Source
Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes
Sarah Hummasti et al. · Circulation Research · 2010
DOI 10.1161/circresaha.110.225698
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